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Michael Noseworthy, PhD, PEng

Full Member of ARiEAL


Professor, Department of Electrical and Computer Engineering, McMaster University

Director, Imaging Physics and Engineering, Imaging Research Centre, St. Joseph’s Healthcare

Special Professional Staff, St. Joseph’s Healthcare (Radiology and Nuclear Medicine)

Engineering Technology Building, Room 406, McMaster University
1280 Main Street West

Email: nosewor@mcmaster.ca

Office Phone: (905) 525-9140 x23727

Websites: 

 

Dr. Michael Noseworthy, in his Master’s degree, developed novel MRI approaches to assess anaesthetic induced liver damage (1992). Subsequently he received a PhD (1996) specializing in applications of MRI/MRS and electron paramagnetic resonance (EPR) methods to assess free radical induced brain damage. From 1997-1999, he was a postdoctoral fellow in Imaging Physics, Sunnybrook Health Sciences Centre performing evaluation of tissue microvasculature through correlative MRI and energy dispersive X-ray microanalysis (EDXS). From 1999-2003, Dr. Noseworthy was a MRI physicist at The Hospital for Sick Children and Assistant Professor in Medical Biophysics and Medical Imaging, University of Toronto. He moved to St. Joseph’s Healthcare in August 2003 and following 3 years as Assistant Professor (Radiology and Medical Physics) at McMaster, Dr. Noseworthy was appointed in Electrical & Computer Engineering, where he is now a full professor. In addition, he is Director of Imaging Physics and Engineering at the Imaging Research Centre, at St. Joseph’s Healthcare, Hamilton. Dr. Noseworthy was the Co-Director of the McMaster School of Biomedical Engineering for 10 years (2010-2020).

Dr. Noseworthy’s research interest is the assessment of tissue microstructure and metabolism using multimodal medical imaging. He focuses considerably on MRI and multinuclear in vivo nuclear magnetic resonance (NMR) spectroscopy. His work involves both imaging hardware and software development and more recently machine learning and deep learning. Dr. Noseworthy is a licensed Professional Engineer in Ontario (PEO) and a member of the Institute of Electrical and Electronics Engineers (IEEE), International Society for Magnetic Resonance in Medicine (ISMRM) and European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).

 



Representative Publications

Anand, S. S., Friedrich, M. G., Desai, D., Schulze, K. M., Awadalla, P., Busseuil, D., … Smith, E. E. (2020). Reduced Cognitive Assessment Scores among Individuals with Magnetic Resonance Imaging-Detected Vascular Brain Injury. Stroke, 51(4), 1158–1165. https://doi.org/10.1161/STROKEAHA.119.028179 (**Dr. Noseworthy was involved in data acquisition, plus editing of each draft of the manuscript).

Považan, M., Mikkelsen, M., Berrington, A., Bhattacharyya, P. K., Brix, M. K., Buur, P. F., … Barker, P. B. (2020). Comparison of multivendor single-voxel MR spectroscopy data acquired in healthy brain at 26 sites. Radiology, 295(1), 171–180. https://doi.org/10.1148/radiol.2020191037 (**Dr. Noseworthy was involved in data acquisition and analysis, plus editing of each draft of the manuscript).

Harasym, D., Turco, C. V., Nicolini, C., Toepp, S. L., Jenkins, E. M., Gibala, M. J., … Nelson, A. J. (2020). Fitness Level Influences White Matter Microstructure in Postmenopausal Women. Frontiers in Aging Neuroscience, 12, 129. https://doi.org/10.3389/fnagi.2020.00129

Ruiter, K. I., Boshra, R., DeMatteo, C., Noseworthy, M., & Connolly, J. F. (2020). Neurophysiological markers of cognitive deficits and recovery in concussed adolescents. Brain Research, 1746, 146998. https://doi.org/10.1016/j.brainres.2020.146998

Ho, R. A., Hall, G. B., Noseworthy, M. D., & DeMatteo, C. (2020). Post-concussive depression: evaluating depressive symptoms following concussion in adolescents and its effects on executive function. Brain Injury, 34(4), 520–527. https://doi.org/10.1080/02699052.2020.1725841

Santos-Díaz, A., & Noseworthy, M. D. (2020). Phosphorus magnetic resonance spectroscopy and imaging (31P-MRS/MRSI) as a window to brain and muscle metabolism: A review of the methods. Biomedical Signal Processing and Control, Vol. 60, p. 101967. https://doi.org/10.1016/j.bspc.2020.101967

Mikkelsen, M., Rimbault, D. L., Barker, P. B., Bhattacharyya, P. K., Brix, M. K., Buur, P. F., … Edden, R. A. E. (2019). Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites. NeuroImage, 191, 537–548. https://doi.org/10.1016/j.neuroimage.2019.02.059

Santos-Díaz, A., Harasym, D., & Noseworthy, M. D. (2019). Dynamic 31 P spectroscopic imaging of skeletal muscles combining flyback echo-planar spectroscopic imaging and compressed sensing. Magnetic Resonance in Medicine, 81(6), 3453–3461. https://doi.org/10.1002/mrm.27682

Santos-Díaz, A., & Noseworthy, M. D. (2019). Comparison of compressed sensing reconstruction algorithms for 31 P magnetic resonance spectroscopic imaging. Magnetic Resonance Imaging, 59, 88–96. https://doi.org/10.1016/j.mri.2019.03.006

McNabb, E., Wong, R., & Noseworthy, M. D. (2019). Differentiating platinum coated brachytherapy seeds and gold fiducial markers with varying off-resonant frequency offsets. Magnetic Resonance Imaging, 60, 68–75. https://doi.org/10.1016/j.mri.2019.04.005

Harasym, D., Nelson, A. J., & Noseworthy, M. D. (2019). Sources of variability and improvements in the measure of gaba using mega-press at 3t. Critical Reviews in Biomedical Engineering, 47(5), 437–455. https://doi.org/10.1615/CritRevBiomedEng.2020030321

Ruiter, K. I., Boshra, R., Doughty, M., Noseworthy, M., & Connolly, J. F. (2019). Disruption of function: Neurophysiological markers of cognitive deficits in retired football players. Clinical Neurophysiology, 130(1), 111–121. https://doi.org/10.1016/j.clinph.2018.10.013

DeMatteo, C. A., Lin, C.-Y. A., Foster, G., Giglia, L., Thabane, L., Claridge, E., … Connolly, J. F. (2019). Evaluating Adherence to Return to School and Activity Protocols in Children After Concussion. Clinical Journal of Sport Medicine, Publish Ahead of Print(00). https://doi.org/10.1097/jsm.0000000000000800

Ho, R. A., Hall, G. B., Noseworthy, M. D., & DeMatteo, C. (2018). An Emotional Go/No-Go fMRI study in adolescents with depressive symptoms following concussion. International Journal of Psychophysiology, 132, 62–73. https://doi.org/10.1016/j.ijpsycho.2017.09.021

McNabb, E., Wong, R., & Noseworthy, M. D. (2018). Resolution and registration in dual-plane co-RASOR MR. Physics in Medicine & Biology, 63(21), 215005. https://doi.org/10.1088/1361-6560/aae4d5


Current Graduate Students / Postdoctoral Fellows

  • , PhD Student, School of Biomedical Engineering, McMaster University
  • Paul Polak, PhD Student, School of Biomedical Engineering, McMaster University 
  • , PhD Student (Co-Supervision), Department of Electrical and Computer Engineering, McMaster University
  • , MASc Student, School of Biomedical Engineering, McMaster University
  • Noah Frank, MEng Student, Department of Electrical and Computer Engineering, McMaster University
  • Ashley Gilbank, MASc Student, School of Biomedical Engineering, McMaster University
  • Neil MacPhee, MASc Student, School of Biomedical Engineering, McMaster University
  • Brian McCrindle, MASc Student, Department of Electrical and Computer Engineering, McMaster University
  • Pranav Rawal, MEng Student, Department of Electrical and Computer Engineering, McMaster University
  • , MASc Student, School of Biomedical Engineering, McMaster University
  • , MASc Student, School of Biomedical Engineering, McMaster University
  • Calvin Zhu, MASc Student, School of Biomedical Engineering, McMaster University